What Causes ED?

ed10ED can be caused by many different factors. Problems are classified as psychological, physical or both. Psychological problems result in 10-20% of all cases. They include stress, anxiety, guilt, depression, low self-esteem and indifference. These patients often fail to respond to psychogenic stimuli. Physical problems account for the majority of cases. Any condition that results in the breakdown of the sequence of events that causes an erection can lead to ED. The most common diseases that cause ED are listed and include diabetes, kidney disease, neurological disease, vascular disease, and malignancies.

  • Peripheral vascular disease, arthrosclerosis (hardening of the arteries), and hypertension (high blood pressure) compromises blood flow to penis
  • Spinal cord injury or stroke impairs nerve conduction to the brain
  • Diabetes impairs peripheral nerve conduction to the penis

ED can also be caused by medications and is known as medication induced ED. There are over 200 possible medications that can alter the ability to have an erection. Possible medications include those listed in the table below. Please consult your physician prior to discontinuing any medication listed.

Drug Class



Antihypertensives and Diuretics Hydrochlorothiazide Esidrix, Hydrodiuril, Inderide, Moduretic, Oretic, Lotensin
Triamterine Maxide, Dyazide
Furosdmide Lasix
Chlorothalidone Hygrotone
Bumetanide Bumex
Guanfacine Tenex
Methyldopa Aldomet
Clonidine Catapres
Verapamil Calan, Isoptin, Verelan
Nifedipine Adalat, Procardia
Hydralazine Apresoline
Captopril Capoten
Enalapril Vasotec
Metoprolol Lopressor
Propranolol Inderal
Labetalol Normodyne
Atenolol Tenormin
Phenoxybenzamine Dibenzyline
Spironolactone Aldactone
Antidepressants, Anti-Anxiety Drugs and Anti-Epileptic Drugs Fluoxetine Prozac
Tranylcypromine Parnate
Sertraline Zoloft
Isocarboxazid Marplan
Amitriptyline Elavil
Amoxipine Asendin
Clomipramine Anafranil
Desipramine Norpramin
Nortriptyline Pamelor
Phenelzine Nardil
Buspirone Buspar
Chlordiazepoxide Librium
Clorazepate Tranxene
Diazepam Valium
Doxepin Sinequan
Imipramine Tofranil
Lorazepam Ativan
Oxazepam Serax
Phenytoin Dilantin
Antihistamines Dimenhydrinate Dramamine
Diphenhydramine Benadryl
Hydroxyzine Vistaril
Meclizine Antivert
Promethazine Phenergan
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Naproxen Anaprox, Naprelan, Naprosyn
Indomethacin Indocin
Parkinson’s Disease Medications Biperiden Akineton
Benztropine Cogentin
Trihexylphenidyl Artane
Procyclidine Kemadrin
Bromocriptine Parlodel
Levodopa Sinemet
Anti-Arrythmics Disopyramide Norpace
Histamine H2-Receptor Antagonists Cimetidine Tagamet
Nizatidine Axid
Ranitidine Zantac
Muscle Relaxants Cyclobenzaprine Flexeril
Orphenadrine Norflex
Prostate Cancer Medications Flutamide Eulexin
Leuprolide Lupron
Chemotherapy Medications Busulfan Myleran
Cyclophosphamide Cytoxan

 Even with over 200 meds that cause or aid in ED, the 3 types of medications that will immediately aid in Ed are meds dealing with Blood Pressure, Diabetes, and Cholesterol.


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